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rosuvastatin is metabolized mainly by cyp2c9 and not extensively metabolized; approximately 10 is recovered as metabolite n -desmethyl rosuvastatin.

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the stellar trial, 13,15,18 mercury trial, 7,19 and pulsar 19 are the major open-label, randomized, multicenter trials to compare rosuvastatin 10, 20, 40, or 80 mg with atorvastatin 10, 20, 40, or 80 mg , pravastatin 10, 20, or 40 mg , and simvastatin 10, 20, 40, or 80 mg across dose ranges for reduction of ldl-c.

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similar to the aneurysm repair score, the rosuvastatin-treated rats had additional integrated endothelium compared with the untreated rats with aneurysms.


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