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A study in 13 rheumatoid arthritis ra patients evaluated the effects of multiple doses of meloxicam on the pharmacokinetics of methotrexate taken once weekly.

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chemically methotrexate, usp is n- 4 2,4-diamino-6-pteridinyl methyl methyl-amino benzoyl -l-glutamic acid.

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in general, the following laboratory tests are recommended as part of essential clinical evaluation and appropriate monitoring of patients chosen for or receiving methotrexate therapy complete haemogram; haematocrit; urinalysis; renal function tests; liver function tests and chest x-ray.

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unexpectedly severe sometimes fatal bone marrow suppression and aplastic anemia have been reported with concomitant administration of methotrexate usually in high dosage along with some nonsteroidal anti-inflammatory drugs nsaids see drug interactions .

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