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What is a package insertA package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumersA package insert typically includes information regarding specific indicationsadministration schedulesdosingside effectscontraindicationsresults from some clinical trialschemical structurepharmacokinetics and metabolism of the specific drugBy carefully reviewing the package insertyou will get the most complete and current information about how to safely use this drugIf you do not have the package insert for the drug you are usingyour pharmacist or physician may be able to provide you with a copy.

The diurnal rhythm of the HPA axis is lost in Cushing’s diseasea syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distributionthinning of the skin with easy bruisabilitymuscle wasting with weaknesshypertensionlatent diabetesosteoporosiselectrolyte imbalanceetcThe same clinical findings of hyperadrenocorticism may be noted during long-term pharmacologic dose corticoid therapy administered in conventional daily divided dosesIt would appearthenthat a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effectsEscape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.

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