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Tegretol carbamazepine stored in a closed container and away from heat and moisture at room temperature.

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Isolated cases of neuroleptic malignant syndrome have been reported both with and without concomitant use of psychotropic drugs.

Substantial evidence of Tegretol’s effectiveness for use in the management of children with epilepsysee INDICATIONS AND USAGE for specific seizure typesis derived from clinical investigations performed in adults and from studies in several in vitro systems which support the conclusion that1the pathogenetic mechanisms underlying seizure propagation are essentially identical in adults and childrenand2the mechanism of action of carbamazepine in treating seizures is essentially identical in adults and children.

Urinary frequencyacute urinary retentionoliguria with elevated blood pressureazotemiarenal failureand impotenceAlbuminuriaglycosuriaelevated BUNand microscopic deposits in the urine have also been reportedThere have been rare reports of impaired male fertility and/or abnormal spermatogenesis.

Antiepileptic drugs should not be discontinued abruptly in patients in whom the drug is administered to prevent major seizures because of the strong possibility of precipitating status epilepticus with attendant hypoxia and threat to lifeIn individual cases where the severity and frequency of the seizure disorder are such that removal of medication does not pose a serious threat to the patientdiscontinuation of the drug may be considered prior to and during pregnancyalthough it cannot be said with any confidence that even minor seizures do not pose some hazard to the developing embryo or fetus.

The prognosis in cases of severe poisoning is critically dependent upon prompt elimination of the drugwhich may be achieved by inducing vomitingirrigating the stomachand by taking appropriate steps to diminish absorptionIf these measures cannot be implemented without risk on the spotthe patient should be transferred at once to a hospitalwhile ensuring that vital functions are safeguardedThere is no specific antidote.

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a few cases of neonatal vomiting, diarrhoea and or decreased feeding have also been reported in association with maternal tegretol use.


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