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Acetylcholinesterase inhibitors may decrease the effectives of prochlorperazineCentrally acting acetylcholinesterase inhibitors may increase the neurotoxic effects of antipsychotic agentsCombining prochlorperazine with alcoholkava kavaCNS depressantsand cannabis may increase the risk of CNS depressant side effectsAntacids may decrease the absorption of prochlorperazineProchlorperazine may cause anticholinergic side effects such as dry mouthconstipationdry eyesdecreased urinary outputand mental confusionCombining agents with similar anticholinergic effects increases the risk of experiencing such adverse eventsProchlorperazine may increase the blood levels of dofetilideTikosynUse of both drugs is not recommendedDeferoxamineDesferalmay increase the risk of experiencing side effects of prochlorperazine treatmentCombination . use has resulted in the prolonged loss of consciousnessMetoclopramideReglanmay increase the side effects of antipsychotic agentsCombination use is not recommendedProchlorperazine may increase the CNS depressant effects of orphenadrineNorflexor paraldehydeParalCombination use is not recommendedCombining prochlorperazine and potassium chloride may result in an increase in the ulcerogenic effect of potassium chlorideKlor-ConCombination use is generally not recommendedCombining prochlorperazine with thalidomideThalomidmay increase the risk of experiencing CNS depressant side effectsThis combination is generally not recommended.

Frequency not reportedHyponatremiahyperglycemiahypoglycemiaincreased appetiteincreased weightimpaired glucose toleranceRef]

For Nausea/VomitingI was given this for nausea that could not be helped with zofranI take it on a as needed bases or when the zofran won’t workI have a lot of stomach issues and I can say this stuff definitely helpsIt does make me a little sleep but I’ll take that any day over feeling sick and throwing upThe down side is the restless side effectI feel like I have to keep moving unless I somehow manage to fall asleepThen I am knocked outSometimes I take valium or benadryl to combat the feelingBut that leaves me groggy and unable to function”

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