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Because serious GI bleedinghepatotoxicityand renal injury can occur without warning symptoms or signsconsider monitoring patients on long-term NSAID treatment with a CBC and a chemistry profile periodically.

CELEBREX is not recommended in patients with severe renal insufficiencysee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY

Celecoxib is a white to off-white powder with a pKa of 11.1sulfonamide moietyCelecoxib is hydrophobiclog P is 3.5and is practically insoluble in aqueous media at physiological pH range.

In adult patients who are known or suspected to be poor CYP2C9 metabolizers based on genotype or previous history/experience with other CYP2C9 substratessuch as warfarinphenytoininitiate treatment with half of the lowest recommended dose.

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